Archive  |  All past issues

The Daily Differential

Archive · An emergency medicine broadsheet

Past Issues

10 issues

Every morning issue is archived here by date. The most recent is always available at the front page.

  1. Monday, April 27, 2026

    Critical Fungal Infections

    Life-threatening fungal infections are uncommon in the average ED, but missing them in the immunocompromised, critically ill, or post-influenza patient can be fatal. Early recognition matters because definitive...

  2. Sunday, April 26, 2026

    Procedural Sedation

    Procedural sedation is core EM practice: it enables painful procedures, reduces distress, and can avoid the OR. Safe sedation requires anticipating airway/respiratory compromise, choosing the right agent, and...

  3. Saturday, April 25, 2026

    Hydrocarbons and Inhaled Agents Toxicity and Poisoning

    These exposures are common, especially in children, industrial workers, and patients with substance use. The immediate threats are airway injury, aspiration pneumonitis, dysrhythmia, hypoxia, and end-organ toxicity...

  4. Friday, April 24, 2026

    Upper GI Bleeding

    Upper GI bleeding (UGIB) ranges from self-limited mucosal bleeding to life-threatening hemorrhagic shock. Early risk stratification, resuscitation, and targeted therapy reduce mortality, rebleeding, and missed...

  5. Thursday, April 23, 2026

    Esophageal Rupture

    Boerhaave syndrome is rare but rapidly fatal if missed; delayed diagnosis sharply increases mediastinitis, sepsis, and mortality. In the ED, it can masquerade as ACS, perforated ulcer, PE, or spontaneous pneumothorax.

  6. Wednesday, April 22, 2026

    Approach to Gastrointestinal Bleeding

    GI bleeding ranges from self-limited to immediately fatal. The ED job is to rapidly identify shock, localize likely source (upper vs lower), start resuscitation, and choose the right consult/admission pathway.

  7. Tuesday, April 21, 2026

    Salicylate Poisoning

    Salicylate toxicity is a classic mixed acid-base disorder that can deteriorate quickly, especially in older adults, children, and patients with delayed recognition. Severe poisoning causes CNS injury, pulmonary...

  8. Monday, April 20, 2026

    Digoxin Toxicity and Poisoning

    Digoxin toxicity can cause life-threatening dysrhythmias, hyperkalemia, and hemodynamic collapse. The presentation is often subtle, and management hinges on early recognition plus timely Fab administration.

  9. Sunday, April 19, 2026

    Extravasation

    Extravasation can range from mild local irritation to tissue necrosis, compartment syndrome, and permanent functional loss. Rapid recognition in the ED can prevent severe morbidity, especially with vesicants like...

  10. Saturday, April 18, 2026

    Wound Management

    Wound care is one of the most common ED tasks and has major implications for infection, cosmesis, tetanus prevention, and function. Good irrigation, closure choice, and timely recognition of high-risk wounds prevent...