At the Bedside
- First move in any reproductive-age patient: urine/serum pregnancy test.
- Positive pregnancy test + pelvic pain/bleeding = ectopic until proven otherwise.
- Key diagnoses to separate:
- Ovarian torsion: sudden unilateral pelvic pain, nausea/vomiting, intermittent episodes, adnexal tenderness/mass. Can occur with normal Doppler flow.
- Ruptured/hemorrhagic ovarian cyst: acute unilateral pain, often mid-cycle or postcoital; may have free fluid and anemia if significant bleed.
- Tubo-ovarian abscess: pelvic pain + fever + discharge/CMT/adnexal tenderness; often PID spectrum.
- Ovarian hyperstimulation syndrome: recent fertility therapy, enlarged ovaries, ascites, hemoconcentration, VTE risk.
- Ovarian neoplasm complications: torsion, rupture, mass effect.
- Exam:
- Vitals: fever, hypotension, tachycardia, shock.
- Abdominal exam: peritonitis suggests rupture/hemoperitoneum, TOA rupture, appendicitis.
- Pelvic exam: discharge, cervical motion tenderness, adnexal tenderness/mass, bleeding.
- Workup:
- Urine/serum hCG.
- CBC, CMP, UA.
- Type & screen if bleeding, significant pain, pregnancy, surgical concern, or unstable.
- GC/CT NAAT, wet prep if discharge/PID concern.
- Transvaginal pelvic ultrasound with Doppler: first-line imaging.
- Torsion findings: enlarged ovary, peripheral follicles, stromal edema, free fluid, twisted pedicle/“whirlpool sign.”
- Normal Doppler does not exclude torsion due to dual ovarian blood supply.
- CT abdomen/pelvis if diagnosis unclear or appendicitis/stone/diverticulitis suspected, but do not delay GYN consult if torsion likely.
- Management:
- Torsion: NPO, IV access, analgesia/antiemetics, urgent GYN consult for diagnostic laparoscopy and detorsion. Ovarian salvage often possible even if ischemic-appearing.
- Ruptured cyst:
- Stable, mild symptoms: analgesia, observation, outpatient GYN follow-up.
- Unstable, falling Hgb, large hemoperitoneum, anticoagulated: resuscitate, type/cross, GYN consult, possible operative management.
- TOA: broad-spectrum antibiotics + GYN admission. Drainage/surgery if rupture, sepsis, pregnancy, large abscess, or no improvement in 48–72 hr.
- OHSS: IV fluids, antiemetics, electrolyte correction, monitor urine output, consider admission for severe ascites, hypoxia, AKI, hemoconcentration, VTE.
- Disposition:
- Admit/OR: suspected torsion, TOA, unstable hemorrhagic cyst, peritonitis, severe OHSS.
- Discharge possible: stable simple/hemorrhagic cyst with controlled pain, reliable follow-up, no pregnancy/ectopic concern, no torsion concern.
Study Directive
- Draw a differential map for female pelvic pain by pregnancy test result.
- Review ultrasound images of torsion: enlarged ovary, peripheral follicles, free fluid, whirlpool sign.
- Practice a 60-second consult script for suspected torsion: age, pregnancy status, pain timing, exam, ultrasound, NPO status, vitals.
- Memorize outpatient PID antibiotics and indications for admission/TOA management.
Recent Literature
- Review or guideline Fertility-sparing treatment and follow-up in patients with cervical cancer, ovarian cancer, and borderline ovarian tumours: guidelines from ESGO, ESHRE, and ESGE
- Recent clinical Coumarin-dihydropyrimidinone hybrids as promising agents against ovarian cancer: synthesis, SAR, and in silico evaluation