An Emergency Medicine Broadsheet
·Phoenix·
Est. MMXXVI
Blue Fish Med · Today's Topic
Penetrating Abdominal Trauma
The abdomen can hide lethal injury behind a tiny skin defect. Missing a hollow viscus or vascular injury is how a “stable” patient becomes a catastrophe.
A 29-year-old man arrives on a backboard in a stiff, blood-speckled shirt, one hand clamped over a small stab wound just below the left costal margin. He’s pale but talking, every breath shallow, the monitor tracing a fast narrow pulse while a paramedic peels off a gauze pad that’s already dark red. In the corner of the bay, a nurse notices his abdomen tightening with each wince, but the wound itself looks deceptively small. The question is whether this is a superficial cut or a hole that has already reached something that matters.
— What’s your move? Read on.
Before you read
What bedside findings are reliable enough to override a “looks stable” patient?
When should FAST, CT, or a local wound exploration actually change management?
When to Think of It
Any stab, gunshot, or impalement to the torso below the nipples and above the groins, especially with peritonitis, evisceration, hemodynamic instability, or an unreliable exam. Think of it when the trajectory could cross the diaphragm, retroperitoneum, mesentery, or solid organs.
Sick or Not Sick
The fork is unstable/peritonitic vs. stable and examinable. If the patient is hypotensive, has diffuse peritonitis, or is too unreliable to examine, assume operative injury until proven otherwise.
The First Fifteen Minutes
Massive hemorrhage or shock → balanced blood product resuscitation with PRBC:plasma:platelets in roughly 1:1:1 ratio; if profound shock, give TXA 1 g IV over 10 min, then 1 g IV over 8 hr within 3 hours of injury, because it slows fibrinolysis.
Hypotension after penetrating trauma → permissive hypotension is not for obvious TBI; otherwise keep perfusion just adequate while activating the trauma team, because crashing patients need source control, not liters of crystalloid.
Open abdominal evisceration or obvious bowel contamination → cover exposed viscera with sterile saline-moistened gauze and an occlusive dressing, because it limits desiccation and contamination.
Pain/anxiety with stable airway and pressure → fentanyl 25–50 mcg IV q5–10 min titrated (or hydromorphone 0.5–1 mg IV), because analgesia improves exam and reduces catecholamine stress.
Suspected bowel injury/open wound with contamination risk → cefazolin 2 g IV now; if gross hollow viscus contamination is likely, add metronidazole 500 mg IV, because early antibiotics reduce infectious complications.
Unclear tetanus status with dirty penetrating wound → Tdap 0.5 mL IM now (plus TIG if indicated by immunization history), because tetanus prophylaxis prevents toxin-mediated disease.
Definitive Care & Disposition
Unstable patients, those with peritonitis, free air, evisceration with concerning exam, or a positive FAST with shock go to the OR for exploratory laparotomy. Stable patients usually get contrast CT of chest/abdomen/pelvis to define trajectory and injury pattern; some require serial abdominal exams or local wound exploration if the wound is superficial and the patient is reliable. Admit all true penetrating abdominal injuries; floor vs ICU depends on hemodynamics, transfusion requirement, associated injuries, and operative findings.
How This One Kills
The fatal miss is assuming a small wound means a minor injury and sending home a patient with a delayed hollow viscus perforation or mesenteric bleed that declares itself hours later with sepsis or exsanguination.
The Differential — What Else Looks Like This
Abdominal wall stab only — no fascial violation on local exploration; confusing it with true penetration leads to unnecessary laparotomy.
Blunt abdominal trauma — lacks a penetrating tract; missing the distinction delays targeted evaluation for bowel/vascular injury.
Lower thoracic injury with diaphragmatic violation — trajectory crosses the diaphragm; confusing it with isolated abdominal injury misses a repairable but dangerous thoracoabdominal injury.
Flank/back soft tissue wound — retroperitoneal injuries can be occult; confusing it with superficial trauma misses duodenal, pancreatic, renal, or vascular injury.
The Second-Day Story
Older adults, intoxicated patients, and those with distracting injuries may look “okay” while bleeding internally. The abdomen may be soft, the wound tiny, and the vitals only mildly abnormal—yet a mesenteric tear or hollow viscus injury can smolder until the patient suddenly becomes febrile, tachycardic, and peritoneal hours later. Treat any unreliable exam with a lower threshold for CT, observation, or operative consultation.
Back to Our Patient
Back to our 29-year-old with the small left upper quadrant stab wound and worsening tachycardia: this is a penetrating abdominal trauma patient with possible transdiaphragmatic or splenic/colonic injury. He is recognized as high risk because the exam is concerning and the wound location is dangerous; if he becomes hypotensive or peritonitic, he goes straight to the OR, and if he remains stable he needs urgent trauma evaluation and contrast CT after initial resuscitation. His wound is covered, blood is prepared if needed, tetanus and antibiotics are addressed, and he is admitted under trauma surgery rather than watched casually.
Patient Presentation to Attending
How you’d present this patient on the floor — tight, pertinent positives and negatives, no rambling
“29-year-old man with a stab wound to the left upper abdomen just below the costal margin, here after assault. He’s tachycardic with abdominal pain and guarding around the wound but no respiratory distress; blood pressure has been borderline but currently holding. I’m concerned for penetrating abdominal injury with possible diaphragmatic, splenic, or hollow viscus involvement. FAST is pending and I’ve activated trauma surgery; we’ve covered the wound, given analgesia, started blood preparation, updated tetanus, and are deciding between immediate OR if he worsens versus CT if he remains stable.”
Study Directive
Sketch the decision tree for penetrating abdominal trauma from memory: unstable/peritonitic → OR; stable → CT/serial exams/LWE as appropriate.
Make a one-page list of injuries by anatomic zone: anterior abdomen, flank/back, thoracoabdominal, and groin.
Practice a 30-second oral sign-out that includes mechanism, hemodynamics, abdominal exam, FAST status, and disposition.
Review your institution’s trauma antibiotic and tetanus prophylaxis pathway for penetrating wounds.
Genitourinary trauma is easy to undercall because the injuries are often hidden. A careless Foley or missed urethral disruption can turn a repairable injury...
A 41-year-old bicyclist sits rigidly on the stretcher, one pant leg cut away, a crescent of bruising tracking across the lower abdomen and a thin ribbon of blood at the urethral meatus. He grimaces every time the nurse asks him to urinate, then admits he hasn’t been able to since the crash. The pelvis x-ray is still pending, but the room has already gone quiet around the question of whether anything can be put in the bladder yet.
Before You Read
Which genital or urinary findings mean “stop” before you catheterize?
When does gross hematuria or mechanism demand imaging?
Which injuries need immediate urology, and which can wait for reconstruction?
Why It Matters
Genitourinary trauma is easy to undercall because the injuries are often hidden. A careless Foley or missed urethral disruption can turn a repairable injury into a complicated one.
When to Think of It
Blood at the meatus, perineal ecchymosis, high-riding prostate, pelvic fracture, inability to void, gross hematuria after blunt trauma, flank pain/hematuria after deceleration, or penetrating injury near the genitals, perineum, flank, or lower abdomen.
Sick or Not Sick
The fork is suspected urethral/bladder injury vs. safe lower urinary tract access. If urethral injury is suspected, do not blindly place a Foley; if bladder rupture is suspected, image before catheterization strategy changes.
The First Fifteen Minutes
Hemodynamic instability from GU bleeding → activate trauma resuscitation with blood products, because GU hemorrhage can be part of pelvic exsanguination.
Suspected urethral injury (blood at meatus, inability to void, pelvic fracture) → no blind Foley; get retrograde urethrogram and urology consult, because instrumentation can worsen a partial or complete disruption.
Pelvic fracture with bleeding concern → pelvic binder placed at the greater trochanters, because pelvic volume reduction reduces hemorrhage.
Pain → fentanyl 25–50 mcg IV q5–10 min titrated, because comfort improves cooperation for imaging and exam.
Open genital/perineal wound → cefazolin 2 g IV now and broaden if gross contamination, because early prophylaxis lowers infectious risk.
Dirty penetrating wound with uncertain tetanus → Tdap 0.5 mL IM now, because tetanus prevention is time-sensitive.
Definitive Care & Disposition
Urethral injury is diagnosed with retrograde urethrogram; bladder injury usually needs CT cystography, especially with pelvic fracture and gross hematuria. Renal trauma management depends on stability and CT findings—many are nonoperative if hemodynamically stable. Testicular torsion, devascularized testis, or major scrotal laceration needs urgent urologic action; the ED role is to protect the organ, image appropriately, and avoid harmful instrumentation. Most true GU trauma is admitted; unstable bleeding or associated pelvic injuries may require ICU and embolization or OR.
How This One Kills
The classic miss is placing a Foley through a disrupted urethra or dismissing gross hematuria after deceleration as “just trauma,” then failing to image a bladder, ureter, or renal injury until urinary leak, infection, or renal loss develops.
The Atypical Presentation
Elderly patients, intoxicated patients, and those with distracting injuries may not report urinary symptoms clearly. Pediatric patients can present with vague lower abdominal pain, inability to void, or blood staining on the diaper rather than obvious hematuria. When the mechanism is suggestive, the absence of dramatic findings does not make the urethra or bladder safe.
Back to Our Patient
Back to our 41-year-old bicyclist with meatal blood, pelvic bruising, and inability to void: this is a suspected urethral injury until proven otherwise. He should not get a blind Foley; instead he needs pelvic stabilization, trauma/urology consultation, and a retrograde urethrogram, with CT or bladder imaging guided by associated findings. His pain is treated, bleeding risk is assessed, and he is admitted because this is not a “wait and see” urinary complaint.
Patient Presentation to Attending
“41-year-old man in a bicycle crash with pelvic pain, blood at the urethral meatus, and inability to void since the injury. He’s hemodynamically stable but has suprapubic tenderness and perineal bruising; I did not place a Foley because I’m concerned for urethral disruption. Pelvic x-ray is pending, and I’ve called urology and trauma. We’re planning retrograde urethrogram first, with further bladder or renal imaging depending on the results and associated injuries.”
Study Directive
Memorize the “no Foley” signs: blood at meatus, high-riding prostate, perineal ecchymosis, pelvic fracture, inability to void.
Draw the imaging sequence from memory: RUG for urethra, CT cystography for bladder, contrast CT for renal injury.
Practice explaining to a consultant why a Foley was deferred in one sentence.
Review your trauma bay’s pathway for pelvic binder placement and GU imaging.
Key Medications
Fentanyl 25–50 mcg IV q5–10 min titrated for pain.
Cefazolin 2 g IV for open genital/perineal wounds; broader coverage may be needed with contaminated injuries.
Tdap 0.5 mL IM if wound prophylaxis indicated and immunization not current.
Dosing and antibiotic breadth vary by wound contamination and local protocols—check a reference if uncertain.
High-Yield Pearls
Blood at the meatus is a “stop sign” for blind Foley placement.
Gross hematuria plus pelvic fracture is bladder injury until proven otherwise.
GU trauma often rides along with pelvic hemorrhage; stabilize the pelvis, not just the urinary tract.
The Mimics
Kidney stone — colicky pain without traumatic mechanism; confusing it with trauma misses associated internal injury.
UTI/urethritis — dysuria without trauma or pelvic fracture; confusing it with trauma delays imaging and specialty care.
Scrotal hematoma from isolated soft tissue injury — intact testicular exam and no severe pain; confusing it with torsion can cost the testis.
BPH/urinary retention — chronic obstructive symptoms without meatal blood or pelvic trauma; confusing it with urethral disruption risks false reassurance.
Board Question
A 26-year-old man after a motor vehicle crash has a pelvic fracture and blood at the urethral meatus. What is the next best step?
APlace a Foley catheter to relieve retention
BRetrograde urethrogram before urethral instrumentation
CStart tamsulosin and discharge
DCT abdomen only, no GU-specific imaging
Reveal answer
Correct: B
Blood at the meatus and pelvic fracture strongly suggest urethral injury, so blind catheterization is contraindicated. Retrograde urethrogram is the standard initial test before any urethral instrumentation.
A 67-year-old woman in a bicycle helmet with a cracked visor is gasping through blood at the corner of her mouth, one eye drifting shut while the monitor shows a pulse of 48 and a blood pressure that is falling. Her husband keeps saying she was talking after the fall, but now she only groans when the nurse pinches her nailbed. The question in the room is no longer what happened to her head—it is how fast the brain can be saved from the rest of the body.
Before You Read
Which TBI findings mean immediate airway, breathing, and perfusion priorities before the scan?
What is the one physiology target that prevents secondary brain injury?
Which patients need neurosurgery now, not after the CT result comes back?
Why It Matters
Major TBI kills from secondary injury—hypoxia, hypotension, and rising intracranial pressure. Early physiology management can change outcome before definitive imaging or surgery.
When to Think of It
GCS 8 or less, declining mental status, focal neurologic deficits, signs of herniation, repeated vomiting, seizure, severe mechanism with abnormal neuro exam, or any head injury with hypoxia/hypotension. Think major TBI in any patient who cannot protect the airway or is worsening on serial exam.
Sick or Not Sick
The fork is airway/protective reflex failure or impending herniation vs. not. If GCS ≤ 8, airway is failing, or herniation is suspected, intubate and treat ICP physiology immediately; if stable and intact, proceed with CT and close neuro monitoring.
The First Fifteen Minutes
Hypoxia or inability to protect airway → rapid sequence intubation with ketamine 1–2 mg/kg IV or etomidate 0.3 mg/kg IV plus rocuronium 1.2 mg/kg IV, because airway control prevents hypoxemia and aspiration.
Systolic BP < 100 mm Hg (or < 110 in older adults, depending on protocol) → isotonic fluids and blood as needed to maintain perfusion, because hypotension worsens secondary brain injury.
Signs of herniation (unilateral blown pupil, posturing, Cushing response, acute decline) → hypertonic saline 3% 2–3 mL/kg IV bolus or mannitol 0.5–1 g/kg IV, because osmotherapy temporarily lowers ICP.
Seizure → lorazepam 2–4 mg IV now, repeat once if needed, then load antiseizure medication such as levetiracetam 60 mg/kg IV (max 4.5 g), because stopping seizures reduces metabolic demand and secondary injury.
Agitation/pain with threatened ICP rise → fentanyl 25–50 mcg IV titrated, because blunt sympathetic surges raise ICP.
If mannitol used → ensure adequate blood pressure and renal perfusion, because it can worsen hypotension or diuresis.
Definitive Care & Disposition
Get noncontrast head CT immediately once the airway and circulation are supported, but do not let scanning delay lifesaving resuscitation. Neurosurgery consultation is early for mass lesions, contusions with shift, EDH/SDH, depressed skull fracture, or any herniation concern. All major TBI patients are admitted, typically ICU; transfer to a trauma/neurosurgical center is needed if local resources cannot support invasive monitoring, decompression, or definitive management.
How This One Kills
The lethal miss is normalizing a transiently “okay” exam while the patient quietly slips into hypoxic, hypotensive secondary brain injury or herniates in the CT scanner queue.
The Atypical Presentation
Older adults on anticoagulants may have only mild headache or confusion before deteriorating. Children may appear sleepy or irritable rather than frankly obtunded. A patient who “woke up and talked” after the crash can still have a rapidly expanding bleed—serial exam matters more than the initial story.
Back to Our Patient
Back to our 67-year-old woman with a declining mental status, bradycardia, and hypotension after the bicycle crash: she has major TBI with a physiology threat from secondary brain injury and possible herniation. Her airway is secured immediately with RSI, blood pressure is supported, and if her exam worsens or pupils change she gets hypertonic saline or mannitol while neurosurgery is activated. CT is obtained only after stabilization, and she is admitted to ICU with a low threshold for operative intervention or transfer.
Patient Presentation to Attending
“67-year-old woman with blunt head trauma from a bicycle crash, now with worsening mental status, bradycardia, and falling blood pressure. She’s only groaning to pain, has abnormal pupils and cannot protect her airway, so I’m treating this as major TBI with concern for impending herniation. I’ve prepared for RSI, started perfusion support, and called neurosurgery and trauma. We’ll get a noncontrast head CT immediately after stabilization, but she needs ICU-level care regardless.”
Study Directive
Rehearse the major TBI first-minute algorithm from memory: airway, oxygen, BP, pupils, CT, neurosurgery.
Write out your institution’s RSI drug choices and hyperosmolar options.
Practice a 20-second explanation of why hypotension is disastrous in TBI.
Compare herniation signs with intoxication and postictal states on flashcards.
Key Medications
Ketamine 1–2 mg/kg IV for RSI induction.
Etomidate 0.3 mg/kg IV for RSI induction.
Rocuronium 1.2 mg/kg IV for RSI paralysis.
3% hypertonic saline 2–3 mL/kg IV bolus for herniation/ICP crisis.
Mannitol 0.5–1 g/kg IV for herniation/ICP crisis; check hemodynamics and renal function.
Lorazepam 2–4 mg IV for seizure.
Levetiracetam 60 mg/kg IV (max 4.5 g) for seizure prophylaxis/treatment loading.
Doses vary by local trauma/neurocritical care pathways; check a reference if uncertain.
High-Yield Pearls
In major TBI, oxygenation and blood pressure are treatments, not just vitals.
A “talkative” patient can still have a dangerous expanding intracranial bleed.
Hyperventilation is not routine; use it only as a temporary bridge for suspected herniation while definitive care is arranged.
The Mimics
Stroke — focal deficit without trauma; confusing it with TBI delays head CT and trauma physiology management.
Intoxication — altered sensorium with a misleading mechanism history; confusing it with TBI misses occult hemorrhage.
Postictal state — transient confusion after seizure; confusing it with TBI misses the need to search for traumatic intracranial bleeding.
Spinal cord injury — neuro deficits with preserved mentation; confusing it with TBI can misdirect the resuscitation priorities.
Board Question
A 54-year-old man with severe head trauma is somnolent, has a GCS of 7, and is intermittently vomiting. What is the best next step?
AObserve until the CT scanner is available
BDelay intubation so his neuro exam remains intact
CSecure the airway with RSI and maintain oxygenation/perfusion
DGive outpatient concussion instructions
Reveal answer
Correct: C
GCS 8 or less and inability to protect the airway are indications for immediate airway control in major TBI. Preventing hypoxia and hypotension is the key early intervention to reduce secondary brain injury.
Minor TBI is common, but a small subset hides intracranial hemorrhage. The job is to identify who needs imaging and who needs strict return precautions and...
A 19-year-old soccer player sits under the bright triage lights, ice pack over one temple, talking in full sentences but blinking hard as if the room is too loud. He says he was “a little dazed” after heading the ball and fell backward onto the grass; now he has a dull headache, nausea, and can’t remember the last few minutes cleanly. His friend keeps asking if he can just sleep it off, and everyone in the room is waiting for someone to decide whether this is just a concussion.
Before You Read
Who with minor head trauma needs CT, observation, or neither?
What red flags turn a “concussion” into a brain bleed until proven otherwise?
What discharge instructions actually prevent missed deterioration?
Why It Matters
Minor TBI is common, but a small subset hides intracranial hemorrhage. The job is to identify who needs imaging and who needs strict return precautions and follow-up.
When to Think of It
Head trauma with headache, amnesia, brief loss of consciousness, confusion, vomiting, dizziness, scalp hematoma, or transient neurologic symptoms, but preserved airway and no major deficits. Think concussion first—but only after you screen for bleed risk.
Sick or Not Sick
The fork is CT-indicated/high-risk vs. low-risk observation/discharge. If there is anticoagulation, age-related risk, repeated vomiting, dangerous mechanism, focal deficit, seizure, worsening headache, or prolonged loss of consciousness/amnesia, CT is favored.
The First Fifteen Minutes
Headache or nausea with stable exam → acetaminophen 650–1000 mg PO and/or ondansetron 4 mg IV/PO, because symptom control helps reassessment; avoid masking worsening with oversedation.
Agitation or significant pain → cautious fentanyl 25–50 mcg IV titrated, because comfort improves cooperation while preserving neuro checks better than deep sedation.
If CT decision is uncertain due to risk factors or anticoagulation → obtain noncontrast head CT, because early imaging rules out clinically important hemorrhage.
If on warfarin/DOAC with concern for bleed and CT positive or strong suspicion → reverse per agent and protocol; examples include 4-factor PCC and agent-specific reversal, because ongoing anticoagulation worsens hemorrhage. Dosing is agent- and institution-specific—check a reference.
Definitive Care & Disposition
CT-negative, reliable, low-risk patients can often be discharged with a responsible observer and strict return precautions. Patients with persistent symptoms, anticoagulation, intoxication, unreliable follow-up, or social concerns may need observation. Any intracranial hemorrhage, worsening symptoms, or neurologic deficit requires admission and neurosurgical/trauma involvement. Concussion care includes cognitive and physical rest with graded return to activity and sports clearance.
How This One Kills
The lethal miss is discharging an anticoagulated or worsening patient as “just a concussion,” then missing a delayed subdural or other evolving bleed.
The Atypical Presentation
Older adults may present with mild confusion, gait change, or a “not themselves” complaint after a seemingly trivial fall. Children can be hard to assess and may present with vomiting, irritability, or behavior change rather than a classic concussion story. In anticoagulated patients, symptoms can be delayed and subtle, so one reassuring exam is not enough.
Back to Our Patient
Back to our 19-year-old soccer player with headache, nausea, and brief amnesia after heading the ball: this sounds most consistent with minor TBI/concussion if he has no red flags on exam and no high-risk features. He gets symptom control, a focused neuro exam, and CT only if his risk profile or course warrants it; if low risk and reliable, he can be discharged with a sober observer and strict return precautions. If symptoms worsen, he returns immediately for reassessment and possible imaging.
Patient Presentation to Attending
“19-year-old male with minor head trauma after a soccer collision, brief confusion, headache, and nausea but no loss of consciousness longer than a minute, no focal deficits, and normal vitals. He’s alert and oriented now, not anticoagulated, and has no concerning neck findings or repeated vomiting. This looks like concussion/minor TBI, so I’m checking him against CT criteria and managing symptoms with acetaminophen and ondansetron. If he remains low risk, I’d discharge him with a responsible adult and clear return precautions.”
Study Directive
Memorize your CT decision rule triggers and rehearse them out loud.
Write a 5-point concussion discharge script from memory.
Compare minor TBI red flags with stroke and intoxication in a quick self-quiz.
Practice a one-line disposition decision for three variants: low risk, anticoagulated, and worsening.
Key Medications
Acetaminophen 650–1000 mg PO.
Ondansetron 4 mg IV/PO.
Fentanyl 25–50 mcg IV titrated if needed.
4-factor PCC and reversal agents for anticoagulants are protocol-dependent; check institutional guidance.
Pediatric dosing and CT decision rules differ by age; use age-specific pathways.
High-Yield Pearls
The decision is not “concussion vs no concussion”; it is “does this patient need CT or observation for occult hemorrhage?”
Anticoagulation and age are high-alert modifiers even when the exam looks normal.
Discharge instructions are part of treatment: worsening headache, repeated vomiting, confusion, seizure, or weakness means immediate return.
The Mimics
Syncope — transient loss of consciousness without post-traumatic amnesia pattern; confusing it with TBI may miss the true cause of collapse.
Migraine — headache with photophobia but no trauma red flags; confusing it with TBI can over-image, but the bigger risk is missing hemorrhage in a “new migraine.”
Alcohol intoxication — slurred speech and confusion after trauma; confusing it with concussion misses intracranial injury.
Cervical spine injury — neck pain or neuro symptoms after head strike; confusing it with isolated concussion misses a spinal lesion.
Board Question
A 22-year-old woman with a mild head injury has a headache, one episode of vomiting, and normal neurologic exam. She is not anticoagulated and has no dangerous mechanism. Best next step?
AImmediate craniotomy
BNoncontrast head CT for all minor head injuries
CRisk-stratify; observation or discharge may be appropriate if she remains low risk
DLumbar puncture
Reveal answer
Correct: C
Not every minor head injury needs CT. Use validated risk factors to decide imaging; low-risk, reliable patients can often be observed briefly or discharged with strict return precautions.
A quick test of recall from prior editions. Commit to an answer before you check.
From yesterday's edition
A 64-year-old man with inferior STEMI becomes hypotensive after a small dose of nitroglycerin. His lungs are clear and JVP is elevated. What’s the diagnosis, and the first move?
Check your answer
Right Ventricular STEMI. Activate STEMI pathway, avoid nitrates if RV infarct suspected, give cautious IV fluids if hypotensive without pulmonary edema, treat bradyarrhythmias, and expedite reperfusion.
From the June 11 edition
Today, three days ago: Haloperidol. What’s the adult ED dose, and the contraindication you’d most regret missing?
Check your answer
Agitation: 2.5–5 mg IV/IM/PO for moderate symptoms; 5–10 mg IM/IV for severe agitation per protocol, often combined with benzodiazepine or antihistamine depending on scenario. Parkinson disease/Lewy body dementia, known QT/TdP risk, severe CNS depression, NMS history caution.
From the June 4 edition
A 74-year-old woman presents with fever, hypotension, tachycardia, and altered mental status. Her lungs are clear, cap refill is delayed, lactate is 6 mmol/L, and bedside ultrasound shows a hyperdynamic left ventricle with a small, collapsible IVC. Which is the best next step?
AHigh-dose furosemide
BImmediate norepinephrine infusion after initial crystalloid resuscitation
CPericardiocentesis
DEmergent thrombolysis
Reveal answer
Correct · B
Immediate norepinephrine infusion after initial crystalloid resuscitation This patient has distributive shock, most consistent with septic shock. After initial fluid resuscitation, norepinephrine is the first-line vasopressor when hypotension persists; pericardiocentesis and thrombolysis are for obstructive shock, and furosemide would worsen perfusion.
Journal Watch
From the FOAMed wire
Notable posts and reviews from the last week, ranked by relevance to today’s lead and source trust.
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Pharmacology Corner
Two drugs for the shift
One antibiotic and one other ED workhorse — selected daily, with sources and last-reviewed dates so every dose is cross-checkable.
Antibiotic of the Day
Amoxicillin-Clavulanate
Aminopenicillin / beta-lactamase inhibitor
Indication
Human/animal bite wounds, odontogenic infection, sinusitis/otitis in selected cases, aspiration-related outpatient coverage, and polymicrobial SSTI when outpatient therapy is appropriate.
What’s your dose? — reveal dosing & cautions
ED Dose
875/125 mg PO q12h for most adult outpatient regimens; 500/125 mg PO q8h alternative. Use liquid/weight-based dosing for children.
Renal Adjustment
Avoid 875 mg tablet when CrCl <30 mL/min; use adjusted lower-dose regimens.
Contraindications
Penicillin anaphylaxis; prior cholestatic jaundice/hepatic dysfunction with amoxicillin-clavulanate.
ED Pearl
Augmentin is usually the oral bite-wound workhorse because it covers Pasteurella, oral anaerobes, and streptococci; TMP-SMX or doxy alone misses key mouth flora.
Hypertensive emergency in selected settings, pregnancy-related severe hypertension, aortic dissection adjunct when appropriate, and neurologic BP control when heart rate/BP profile fits.
What’s your dose? — reveal dosing & cautions
ED Dose
10–20 mg IV over 2 min; repeat or double every 10 min to effect per protocol, or infusion 0.5–2 mg/min. Pregnancy severe HTN regimens often use 20/40/80 mg stepwise dosing.
Renal Adjustment
No renal adjustment; hepatic metabolism.
Contraindications
Asthma/COPD with active bronchospasm, bradycardia, heart block, cardiogenic shock, decompensated heart failure, cocaine/stimulant toxicity caution depending on scenario.
BP, HR, bronchospasm, fetal/maternal status in pregnancy, signs of heart failure.
ED Pearl
Labetalol is attractive when tachycardic hypertension needs control; it is the wrong reflex in bradycardia, bronchospasm, heart block, or crashing pump failure.
For educational use only. Verify dosing against the FDA label and your institution’s pharmacy resources before administering.
ECG of the Day
Rhythm
Atrial Fibrillation
Irregularly irregular rhythm without organized P waves — management depends on stability, duration, trigger, and stroke risk.
The Tracing
A 74-year-old woman with pneumonia presents tachycardic and short of breath. The ECG shows an irregularly irregular narrow-complex rhythm at 142 bpm with no consistent P waves and a fibrillatory baseline. Her blood pressure is stable, but she is febrile and hypoxic. The rhythm is real, but the infection is driving it.
Fibrillatory baseline may be visible, especially in V1
QRS is usually narrow unless baseline bundle branch block, aberrancy, pre-excitation, or ventricular pacing is present
Ventricular rate can be slow, controlled, rapid, or extremely rapid in pre-excited AF
Pearls
Treat the patient, not just the rate. Sepsis, PE, alcohol withdrawal, thyrotoxicosis, pain, hypovolemia, and hypoxia commonly drive AF with RVR.
Unstable AF gets synchronized cardioversion when the rhythm is causing instability.
Irregular wide-complex AF should trigger a pre-excitation check before AV nodal blockers.
Pitfalls
Do not cardiovert stable AF of unclear duration without thinking about anticoagulation/stroke risk and local protocol.
Do not miss atrial flutter with variable block; it can look irregular.
Do not reflexively stack AV nodal blockers in a patient whose RVR is compensatory for shock.
At the Bedside
Determine stability first. If unstable from AF, cardiovert. If stable, treat triggers, choose rate/rhythm strategy per duration/comorbidities, and address anticoagulation/disposition.
For educational use only. Verify ECG interpretation against the LITFL entry and your institution’s practice before clinical decision-making.
Case of the Day
From the lead · Penetrating Abdominal Trauma
Self-Examination
Test Your Understanding
A 34-year-old man has a stab wound to the left flank. He is alert, BP 124/78, HR 108, and has localized tenderness but no frank peritonitis. Which is the best next step?
ADischarge with oral antibiotics and return precautions
BExploratory laparotomy immediately
CContrast-enhanced CT of the abdomen and pelvis after trauma consultation
DNo imaging; observe for 6 hours only
Reveal answer
Correct answer · C
Stable patients with penetrating abdominal trauma generally require trauma consultation and contrast CT to define trajectory and detect occult injury. Immediate laparotomy is reserved for instability or peritonitis, and discharge is unsafe because bowel, vascular, or diaphragmatic injuries can be occult.
Study Pace4 topics today; 120 remaining; Day 13 of 43Deadline · June 1, 2026