An Emergency Medicine Broadsheet
·Phoenix·
Est. MMXXVI
Blue Fish Med · Today's Topic
Measuring Temperature
A temperature is a measurement, not a diagnosis—and an inaccurate measurement can delay sepsis care or mislabel toxic hyperthermia as ordinary fever. Route, device, patient factors, and clinical context all determine whether the number deserves trust.
Also known asthermometry · temperature measurement
A 74-year-old woman arrives shivering beneath two hospital blankets, her forehead cool to the touch despite a flushed face. Her daughter says she was “burning up” at home, but the triage temporal scanner reads 37.4°C. She is tachycardic, mildly confused, and breathing faster than usual; the team is debating whether the number is reassuring. The next temperature has not yet been obtained.
— What’s your move? Read on.
Before you read
When does a “normal” reading fail to exclude dangerous illness?
How do fever, hypothermia, and hyperthermia change immediate management?
When to Think of It
Use temperature measurement to detect fever, hypothermia, occult sepsis, environmental exposure, endocrine crisis, medication toxicity, and heat illness. Fever is generally ≥38.0°C (100.4°F) rectally or orally, but dangerous infection may occur without fever, especially in older adults, neonates, immunocompromised patients, and those taking antipyretics. Core temperature is particularly important when heat stroke or severe hypothermia is possible.
Sick or Not Sick
The key call is whether the patient is physiologically unstable or has a temperature-measurement problem that could conceal an emergency. Altered mental status, shock, respiratory distress, seizure, severe rigidity, or suspected heat illness/hypothermia overrides a reassuring peripheral reading.
The First Fifteen Minutes
Confirm the reading with a reliable method; in an unstable patient, obtain a rectal temperature or esophageal/bladder temperature if already instrumented, because peripheral sites can substantially underestimate core temperature.
If suspected heat stroke—core temperature usually ≥40°C plus CNS dysfunction—move immediately to active cooling: remove clothing, mist with water and use fans, and apply ice packs to neck, axillae, and groin, because evaporative and conductive heat loss rapidly reduce core temperature.
If shivering hypothermia with core temperature <32°C, begin active external rewarming; use warmed IV crystalloid 1–2 L IV, typically warmed to 40–42°C, because it limits ongoing heat loss.
Do not give acetaminophen or ibuprofen simply to normalize a number; antipyresis does not treat the cause and is not effective for environmental hyperthermia.
Definitive Care & Disposition
Treat the underlying syndrome: sepsis evaluation and antibiotics when indicated, toxicologic consultation for sympathomimetic or anticholinergic hyperthermia, endocrine evaluation for thyroid storm, and rewarming escalation for severe hypothermia. Avoid relying on oral, axillary, forehead, or tympanic readings when perfusion is poor, the patient is intubated, or temperature extremes are suspected. Heat stroke, severe hypothermia, persistent altered mental status, or measurement discordance in a critically ill patient warrants ICU-level care.
How This One Kills
The lethal error is accepting a falsely normal temporal or axillary temperature in a patient with shock or heat illness, delaying core measurement and active treatment while cellular injury continues.
The Differential — What Else Looks Like This
Fever — regulated hypothalamic set-point elevation with preserved thermoregulatory responses; confusing it with hyperthermia delays cooling.
Heat stroke — uncontrolled temperature elevation with CNS dysfunction; confusing it with infection alone delays immediate cooling.
Measurement artifact — peripheral reading discordant with the patient’s appearance and physiology; confusing it with true normothermia creates false reassurance.
Hypothermia — core temperature <35°C; confusing cold skin with adequate core temperature can miss severe systemic illness.
The Second-Day Story
Older or immunocompromised patients may have sepsis with a normal or low temperature, while antipyretics, steroids, environmental exposure, and poor peripheral perfusion degrade the signal further. A cool forehead does not establish normothermia, and a warm skin surface does not prove fever. In a sick patient, repeat with a core-proximal method and let perfusion, mental status, respiratory effort, and lactate—not the isolated number—drive urgency.
Back to Our Patient
Back to the 74-year-old woman: her tachycardia, tachypnea, and confusion make the temporal reading unreliable and trigger immediate reassessment. A rectal temperature is 39.2°C, confirming fever; she undergoes sepsis evaluation, cultures, lactate testing, and empiric treatment based on the suspected source. The Recognize step is identifying a potentially septic older adult despite a reassuring peripheral number; the Risk Stratify step is recognizing altered mentation and abnormal vital signs as high risk; the First Fifteen step is obtaining a core-proximal temperature while stabilizing and investigating her. She is admitted for monitored treatment of suspected sepsis.
Patient Presentation to Attending
How you’d present this patient on the floor — tight, pertinent positives and negatives, no rambling
“This is a 74-year-old woman with acute confusion, chills, tachycardia, and tachypnea after reported fever at home. Her temporal temperature is 37.4°C, but that conflicts with her appearance and physiology; she has no obvious external heat exposure, and the initial exam shows altered mentation without focal neurologic deficit. I’m concerned that the peripheral reading is falsely reassuring and that she may have occult sepsis. I’ll repeat a rectal temperature, obtain IV access, glucose, CBC, CMP, lactate, blood cultures, urinalysis and imaging guided by symptoms, and start empiric antibiotics if a bacterial source remains likely. Given her abnormal mental status and vital signs, she needs monitored admission.”
Study Directive
Demonstrate rectal, oral, tympanic, temporal, and axillary technique and list the major sources of error for each.
Memorize fever ≥38.0°C, hypothermia <35°C, and the heat-stroke pattern of extreme temperature plus CNS dysfunction.
Practice three scenarios in which the measured temperature should be distrusted: shock, neonate, and suspected heat illness.
Review your institutional device instructions and compare them with an emergency medicine reference on temperature measurement.
More in Today's Issue
3 additional topics
2 of 4
New and Emerging Infections
Emerging infections can spread rapidly through healthcare settings while routine testing is negative or unavailable. The emergency clinician must manage the...
A 32-year-old veterinarian sits upright in the resuscitation bay, coughing into a surgical mask while the smell of disinfectant mixes with wet wool from his jacket. For five days he has had fever, myalgias, and worsening dyspnea; yesterday, two goats on his farm died suddenly. His oxygen saturation is 88% on room air, and the chest radiograph shows bilateral patchy opacities. The team has not yet decided how to protect itself or which specimens to send.
Before You Read
What features should trigger an emerging-infection response rather than routine pneumonia management?
Which immediate actions protect staff and preserve diagnostic options?
When should empiric sepsis therapy proceed before the pathogen is known?
Why It Matters
Emerging infections can spread rapidly through healthcare settings while routine testing is negative or unavailable. The emergency clinician must manage the patient, protect others, notify public health, and preserve a specimen pathway simultaneously.
When to Think of It
Enter the differential when severe or unusual illness follows a cluster, animal exposure, healthcare exposure, outbreak, travel, vector bite, novel medication, or unexplained epidemiologic link. Red flags include rapidly progressive pneumonia, hemorrhagic features, encephalitis, severe diarrhea with dehydration, unusual rash, acute flaccid weakness, or disease in multiple linked people.
Sick or Not Sick
The single most important call is whether the patient has a potentially transmissible high-consequence syndrome. Respiratory failure, shock, encephalopathy, bleeding, or rapidly progressive disease requires resuscitation in parallel with airborne/contact precautions and immediate infection-prevention and public-health notification.
The First Fifteen Minutes
Place the patient in a single room; use airborne, contact, and eye protection when aerosolization or a high-consequence respiratory infection is possible, because source control protects staff and other patients.
Apply a surgical mask to the patient if tolerated, limit personnel and procedures, and notify infection prevention, hospital leadership, and the local/state health department.
If hypoxemic, give oxygen by the least aerosol-generating method that achieves adequate saturation; for respiratory failure, use a negative-pressure room and a fit-tested respirator for staff.
If septic shock or high suspicion for bacterial pneumonia, give ceftriaxone 2 g IV plus azithromycin 500 mg IV, because early antibacterial therapy covers common severe pneumonia while testing proceeds. Add vancomycin 15–20 mg/kg IV when MRSA risk or severe necrotizing pneumonia is present; dosing varies by renal function and institutional protocol.
If shock persists after 30 mL/kg IV balanced crystalloid, start norepinephrine 0.05–0.1 mcg/kg/min IV infusion, titrated to MAP ≥65 mmHg, because vasoconstriction restores perfusion while the source is investigated.
Definitive Care & Disposition
Obtain a focused exposure/travel timeline, contacts, vaccination history, onset dates, and animal/vector details. Coordinate blood, respiratory, stool, skin, or CSF specimens with the laboratory and public health before collection; avoid unapproved aerosol-generating procedures. Admit hypoxemic or systemically ill patients; ICU care is indicated for escalating oxygen needs, shock, encephalopathy, bleeding, or inability to maintain isolation safely. Use pathogen-specific therapy only with infectious disease/public-health guidance when the organism is suspected.
How This One Kills
The dangerous failure is treating an unusual contagious illness as routine pneumonia, allowing an unmasked patient, unprotected staff, and aerosol-generating procedures to create a healthcare-associated cluster before anyone calls infection control.
The Atypical Presentation
Partially treated patients may have little fever, a negative initial respiratory panel, or nonspecific fatigue and dyspnea. Immunocompromised patients may lack leukocytosis or radiographic findings early. The signal is reconstructed from time, geography, contacts, animals, occupations, clusters, and disease severity; a negative routine test does not erase a compelling epidemiologic pattern.
Back to Our Patient
Back to the 32-year-old veterinarian: the goat deaths, severe pneumonia, and hypoxemia trigger recognition of a potentially transmissible emerging zoonosis rather than uncomplicated outpatient pneumonia. He is masked and isolated, staff use airborne/contact/eye protection, infection prevention and public health are called, and carefully coordinated respiratory and blood specimens are obtained. Because he is hypoxemic, he receives oxygen; because severe bacterial pneumonia cannot yet be excluded, ceftriaxone and azithromycin are started, with escalation to norepinephrine if shock develops. He is admitted to an airborne-capable ICU for respiratory support and pathogen-specific management with public-health guidance.
Patient Presentation to Attending
“This is a 32-year-old veterinarian with five days of fever, myalgias, and progressive dyspnea after two goats on his farm died suddenly. He is hypoxemic at 88% on room air with bilateral patchy infiltrates; the key negatives are no known aspiration, medication reaction, or thromboembolic history. I’m concerned about severe pneumonia from a potentially transmissible zoonotic infection, while typical bacterial pneumonia remains possible. He is masked and isolated, staff are using airborne/contact/eye protection, and I’m notifying infection prevention and public health. I’ll obtain coordinated blood and respiratory specimens, start oxygen and empiric ceftriaxone plus azithromycin, and admit him to the ICU.”
Study Directive
Build a one-minute emerging-infection history: contacts, clusters, travel, animals, vectors, healthcare exposure, occupation, and vaccination.
Memorize the local pathway for infection prevention, laboratory notification, and public-health reporting.
Run a tabletop drill for a masked febrile patient requiring intubation; identify PPE, room, personnel, and specimen steps.
Review current CDC/state health department alerts and your institution’s high-consequence pathogen protocol.
Key Medications
Ceftriaxone 2 g IV q24h plus azithromycin 500 mg IV q24h for severe community-acquired pneumonia.
Vancomycin 15–20 mg/kg IV q8–12h when MRSA coverage is indicated; use pharmacy/AUC or institutional dosing guidance.
Norepinephrine 0.05–0.1 mcg/kg/min IV infusion, titrate to perfusion/MAP; concentration and dosing vary by protocol.
Balanced crystalloid 30 mL/kg IV for septic shock or hypoperfusion, with reassessment in heart or renal failure. Pediatric and pregnancy regimens differ; consult institutional infectious disease and public-health protocols.
High-Yield Pearls
Epidemiology can be more diagnostic than the first laboratory panel.
Infection-control actions are clinical treatment: the “second patient” may be a nurse, roommate, or procedure team.
Do not let diagnostic uncertainty delay resuscitation or empiric therapy for shock and severe pneumonia.
The Mimics
Typical bacterial pneumonia — no epidemiologic cluster or unusual exposure; confusing it with an emerging infection spreads disease.
Pulmonary embolism — pleuritic pain and hypoxemia with thrombotic risk but no infectious prodrome; confusing it with infection delays anticoagulation and imaging.
Anaphylaxis — abrupt onset after exposure with urticaria, angioedema, or wheeze; confusing it with infection delays epinephrine.
Noninfectious pneumonitis — exposure-related inflammation without transmissibility; confusing it with infection leads to inappropriate isolation or missed immunosuppression.
Board Question
A patient with rapidly progressive pneumonia after exposure to several ill household members arrives in respiratory distress. What is the most appropriate immediate action?
APerform bronchoscopy before applying precautions
BPlace the patient in a shared room and obtain routine PCR testing
CIsolate the patient, use appropriate PPE, and notify infection prevention/public health
DDelay all treatment until the pathogen is identified
Reveal answer
Correct: C
A concerning epidemiologic cluster plus severe disease requires immediate transmission-based precautions and notification. Stabilization, diagnostic sampling, and empiric treatment proceed in parallel.
A focused overview of emerging mosquito-borne flaviviruses that can sharpen exposure-based ED evaluation of undifferentiated febrile, neurologic, or hemorrhagic illness.
Poliovirus can cause irreversible motor-neuron injury and silent community transmission. The emergency priority is not merely naming the virus—it is...
A 7-year-old boy’s soccer cleats sit untouched beside the stretcher, still crusted with red dirt from the weekend tournament. His mother says he had fever and sore muscles three days ago, then woke unable to climb stairs; today his legs feel heavy and his voice sounds nasal. He is alert, afebrile, and breathing comfortably for now, but his reflexes are reduced in both legs. The next question is whether the weakness will remain limited—or move toward his breathing muscles.
Before You Read
What pattern distinguishes poliomyelitis from other causes of acute flaccid weakness?
Which respiratory and bulbar findings demand early escalation?
What specimens and public-health actions are time-sensitive?
Why It Matters
Poliovirus can cause irreversible motor-neuron injury and silent community transmission. The emergency priority is not merely naming the virus—it is recognizing impending ventilatory failure and preventing additional spread.
When to Think of It
Think of polio with a febrile prodrome followed by asymmetric acute flaccid paralysis, reduced tone and reflexes, preserved sensation, myalgia, meningismus, or bulbar dysfunction. Ask about immunization, travel or exposure to outbreak areas, sanitation, contacts, and stool illness. Respiratory muscle weakness may be subtle before overt distress.
Sick or Not Sick
The critical call is whether there is bulbar or respiratory muscle involvement. Measure forced vital capacity if feasible, serially assess cough, secretion handling, voice, swallowing, neck flexion, and work of breathing, and involve PICU/anesthesia early if function is declining.
The First Fifteen Minutes
Place the patient on contact precautions and notify infection prevention and public health, because poliovirus spreads primarily by fecal-oral transmission and suspected cases require urgent reporting.
Obtain continuous pulse oximetry and serial respiratory assessments; pulse oximetry can remain normal until ventilatory failure is advanced.
If hypoxemia or respiratory fatigue develops, support ventilation early with expert airway involvement; avoid sedating medications unless necessary because they can worsen hypoventilation and obscure neurologic progression.
For significant pain or fever, give acetaminophen 15 mg/kg PO/IV q6h PRN, maximum 75 mg/kg/day or 4 g/day, because it provides analgesia without respiratory depression.
If unable to protect the airway or with progressive ventilatory failure, proceed to controlled intubation with pediatric airway expertise; medication dosing is weight- and protocol-dependent, so confirm with a pediatric resuscitation reference.
Definitive Care & Disposition
Admit suspected poliomyelitis to a monitored pediatric setting; PICU for bulbar dysfunction, declining FVC, weak cough, secretion burden, or evolving respiratory failure. Collect two stool specimens 24–48 hours apart, ideally within 14 days of paralysis onset, plus throat swab/CSF as directed by public health; CSF may show lymphocytic pleocytosis but is not reliably diagnostic. MRI spine/brain and CSF studies help exclude mimics. Treatment is supportive: respiratory therapy, aspiration prevention, nutrition, physical medicine, and rehabilitation. Vaccination and contact management are coordinated with public health.
How This One Kills
The fatal miss is waiting for oxygen desaturation before recognizing neuromuscular ventilatory failure; a child can have normal saturation while vital capacity collapses.
The Atypical Presentation
Vaccinated patients may have partial protection and milder or nonspecific illness, while young children may describe weakness poorly. Paralysis can begin focally, and respiratory failure may present as weak cough, whispering voice, poor feeding, or fatigue rather than hypoxemia. Serial examination and a vaccination/travel/contact history are more valuable than a single normal respiratory measurement.
Back to Our Patient
Back to the 7-year-old boy: fever followed by acute asymmetric flaccid leg weakness and reduced reflexes makes poliomyelitis a critical consideration, while acute flaccid myelitis and Guillain-Barré remain competing diagnoses. He is placed on contact precautions, public health is notified, and continuous respiratory monitoring begins; his weak cough and nasal voice prompt PICU consultation despite normal oxygen saturation. Stool specimens and directed neurologic testing are arranged, and acetaminophen is given for discomfort. He is admitted to the PICU for serial respiratory examinations and supportive care while confirmatory testing and public-health investigation proceed.
Patient Presentation to Attending
“This is a previously healthy 7-year-old boy with a three-day febrile myalgic illness followed by acute bilateral, somewhat asymmetric leg weakness and difficulty climbing stairs. He is alert and currently oxygenating normally, but has reduced lower-extremity tone and reflexes, a weak cough, and a nasal voice without a sensory level or altered mental status. I’m concerned about poliomyelitis or another acute flaccid paralysis syndrome with early bulbar involvement. I’ll place him on contact precautions, notify public health, obtain serial respiratory measurements and neurologic exams, send stool specimens as directed, and involve PICU and neurology now. He needs monitored admission because respiratory failure can precede desaturation.”
Study Directive
Draw a bedside comparison of polio, Guillain-Barré syndrome, acute flaccid myelitis, transverse myelitis, botulism, and spinal cord compression.
Practice documenting strength, tone, reflexes, sensation, cranial nerves, cough, swallow, and neck flexion.
Review your local suspected-polio reporting and specimen-collection pathway.
Work through one pediatric neuromuscular respiratory-failure case using serial FVC/NIF and PICU consultation triggers.
Key Medications
Acetaminophen 15 mg/kg PO/IV q6h PRN, maximum 75 mg/kg/day or 4 g/day.
No proven antiviral treatment routinely reverses paralytic poliomyelitis; supportive care and public-health management are definitive.
Airway medications and paralytic dosing are weight-based and protocol-dependent; use PALS/local pediatric airway guidance. Pediatric dosing must be weight-based; consult Lexicomp, UpToDate, or institutional protocol when uncertain.
High-Yield Pearls
Normal oxygen saturation does not reassure against impending neuromuscular respiratory failure.
Preserve stool specimens early; late or poorly collected samples can compromise confirmation and outbreak control.
Acute flaccid paralysis is a public-health emergency even before the etiology is proven.
The Mimics
Guillain-Barré syndrome — usually symmetric ascending weakness with areflexia and no febrile paralytic prodrome; confusing it with polio delays public-health containment.
Acute flaccid myelitis — often asymmetric weakness with spinal cord gray-matter lesions; confusing it with polio misdirects surveillance and specimen strategy.
Transverse myelitis — sensory level, pain, and upper motor-neuron evolution; confusing it with polio misses spinal cord compression/inflammation.
Botulism — descending paralysis with fixed/dilated pupils or autonomic findings; confusing it with polio delays antitoxin.
Board Question
Which finding most strongly supports poliomyelitis over Guillain-Barré syndrome?
ASymmetric ascending weakness
BAlbuminocytologic dissociation in CSF
CAsymmetric acute flaccid paralysis after a febrile prodrome
DAreflexia with autonomic instability
Reveal answer
Correct: C
Poliomyelitis classically causes asymmetric lower motor-neuron weakness after a nonspecific febrile illness. Guillain-Barré is more often symmetric and ascending, with albuminocytologic dissociation.
Clarifies how IPV and OPV shape individual and population immunity, helping residents assess polio risk in acute flaccid paralysis and recognize the need for immediate public-health notification.
In infants younger than 28 days, fever may be the only sign of bacteremia, meningitis, UTI, or HSV. A well-appearing appearance cannot safely overrule age,...
An 18-day-old girl lies swaddled in her father’s arms, her bottle untouched and her breathing intermittently grunting. The parents measured 38.2°C rectally at home; in the department she is quiet, pale, and difficult to wake but not dramatically ill-looking. Her diaper is dry, and the examination offers no obvious source. The team must decide how much testing and treatment this tiny patient needs before the next vital sign changes.
Before You Read
Which febrile infants require a full invasive evaluation and admission?
When are empiric antibiotics and acyclovir justified?
Which reassuring features are not reassuring enough?
Why It Matters
In infants younger than 28 days, fever may be the only sign of bacteremia, meningitis, UTI, or HSV. A well-appearing appearance cannot safely overrule age, documented rectal temperature, or evolving abnormal behavior.
When to Think of It
Fever is a rectal temperature ≥38.0°C (100.4°F) in an infant. High-risk features include age <28 days, ill appearance, poor feeding, lethargy, abnormal cry, respiratory distress, hypothermia, decreased urine output, petechiae, bulging fontanelle, seizure, or focal infection. Risk assessment also depends on inflammatory markers, urinalysis, and reliable follow-up—not appearance alone.
Sick or Not Sick
The key call is age plus appearance. A febrile infant <28 days, or any infant who appears ill at any age, is high risk and generally requires blood, urine, and CSF evaluation, empiric IV therapy, and hospital admission.
The First Fifteen Minutes
Stabilize airway, breathing, circulation; check bedside glucose and obtain IV access. If glucose is <60 mg/dL with symptoms or inability to feed, give D10W 5 mL/kg IV, because it rapidly corrects neuroglycopenia without excessive glucose concentration.
Obtain blood culture, CBC with differential, inflammatory markers, catheterized urinalysis/culture, and lumbar puncture when safe; do not delay antibiotics for an unsuccessful LP in an unstable infant.
For a febrile infant <28 days, give ampicillin 50 mg/kg IV q6h plus gentamicin 4–5 mg/kg IV q24h for empiric coverage of GBS, Listeria, and gram-negative pathogens; meningitis dosing and neonatal age/renal adjustments vary—check a pediatric reference.
If HSV is possible—vesicles, seizures, hypothermia, mucosal lesions, maternal HSV history, transaminitis, thrombocytopenia, or unexplained sepsis—add acyclovir 20 mg/kg IV q8h, adjusted for renal function, because early therapy reduces neurologic morbidity.
If meningitis is strongly suspected and local protocol favors a third-generation cephalosporin, use cefotaxime 50 mg/kg IV q6–8h; dosing varies with age and meningitis status, so verify locally.
Definitive Care & Disposition
Admit all febrile infants <28 days, generally to a pediatric inpatient or NICU setting. Continue IV antimicrobials until cultures and clinical evaluation permit narrowing; tailor therapy to source and susceptibilities. Infants 29–60 days may qualify for selective testing and observation only if well appearing, inflammatory markers are reassuring, urine testing is negative, CSF strategy is appropriate, and follow-up is reliable. Never use a negative viral test to dismiss bacterial infection risk in a young infant.
How This One Kills
The catastrophic miss is discharging a “well-appearing” neonate with bacteremia, meningitis, or HSV because the fever resolved or the initial exam looked normal.
The Atypical Presentation
Neonates may be hypothermic rather than febrile, feed poorly rather than complain of pain, or simply become sleepy and gray. A normal WBC count, a transiently improved appearance, or a positive viral assay does not reliably exclude invasive bacterial infection. Recheck perfusion, feeding, urine output, tone, and respiratory effort repeatedly while obtaining age-appropriate cultures.
Back to Our Patient
Back to the 18-day-old girl: the documented rectal fever, poor feeding, lethargy, grunting, and age place her in the highest-risk group despite the lack of a focal source. She receives immediate stabilization, glucose testing, cultures, catheterized urine studies, lumbar puncture when safe, and empiric ampicillin plus gentamicin; acyclovir is added while HSV risk is assessed because neonatal HSV can present as sepsis without vesicles. She is admitted for IV therapy and continuous monitoring, with escalation to intensive care if respiratory or perfusion abnormalities progress.
Patient Presentation to Attending
“This is an 18-day-old girl with a documented rectal temperature of 38.2°C, poor feeding, decreased urine output, intermittent grunting, and increased sleepiness. She is pale and difficult to arouse but has no vesicles, focal rash, or obvious source; the important negatives do not lower her age-based risk. I’m concerned about invasive bacterial infection or neonatal HSV with possible early respiratory compromise. I’ll obtain glucose, blood and urine cultures, inflammatory markers, and CSF when safe, start IV ampicillin and gentamicin, add acyclovir while evaluating HSV risk, and admit her for continuous monitoring and empiric treatment.”
Study Directive
Memorize the fever pathways for 0–21 days, 22–28 days, and 29–60 days, including testing and admission thresholds.
Practice a complete febrile-infant order set from memory, including catheterized urine and HSV triggers.
Review neonatal antibiotic dosing with your pharmacist and write down the local ampicillin, gentamicin, cefotaxime, and acyclovir protocols.
Work through three cases where the infant is hypothermic, viral-test positive, or transiently well appearing.
Key Medications
Ampicillin 50 mg/kg IV q6h; use meningitis dosing and neonatal-age adjustments per protocol.
Gentamicin 4–5 mg/kg IV q24h; interval and monitoring vary with gestational/postnatal age and renal function—check a neonatal dosing reference.
Acyclovir 20 mg/kg IV q8h when HSV is suspected; adjust for renal function and verify neonatal protocol.
Cefotaxime 50 mg/kg IV q6–8h when indicated for neonatal meningitis or gram-negative coverage; meaningful age-specific variability requires reference checking.
D10W 5 mL/kg IV for symptomatic hypoglycemia, then recheck glucose. Do not substitute ceftriaxone casually in neonates, especially with hyperbilirubinemia or calcium-containing IV products.
High-Yield Pearls
In neonates, hypothermia can be the presenting temperature abnormality of sepsis.
A positive viral test reduces neither the need for age-appropriate evaluation nor the risk of concomitant UTI.
Absence of vesicles does not exclude disseminated neonatal HSV.
The Mimics
Overheating/environmental elevation — temperature normalizes after removing excess clothing and the infant remains well; confusing it with fever can overtest, but assuming it explains a documented rectal fever can miss sepsis.
Viral bronchiolitis — respiratory symptoms with wheeze/crackles; a viral appearance does not exclude UTI, bacteremia, or apnea in a neonate.
Roseola or other viral exanthem — rash after fever; confusing it with invasive bacterial disease delays treatment when the child is toxic.
Serious bacterial infection — documented fever with poor feeding, lethargy, abnormal perfusion, or inflammatory markers; undercalling it is the dangerous error.
Board Question
A 20-day-old infant has a rectal temperature of 38.1°C but appears well after feeding in the ED. What is the best management?
ADischarge with antipyretics and 24-hour follow-up
BUrinalysis only, because most infections are urinary
CFull sepsis evaluation, empiric IV antibiotics, and admission
DRespiratory viral testing and discharge if negative
Reveal answer
Correct: C
Infants younger than 28 days with documented fever are high risk regardless of transient well appearance. They generally require blood, urine, and CSF evaluation, empiric IV antibiotics, and hospitalization.
Provides an emergency medicine–focused framework for age-stratified risk assessment, diagnostic testing, and disposition of febrile infants and children.
Yesterday’s Differential
The daily puzzle — from editions past
A quick test of recall from prior editions. Commit to an answer before you check.
From yesterday's edition
A 58-year-old patient with palpitations has a regular wide-complex tachycardia at 165 bpm. The team debates SVT with aberrancy because he is awake and talking. What’s the diagnosis, and the first move?
Check your answer
VT vs SVT with Aberrancy. Assess stability first. Cardiovert unstable patients. For stable regular WCT, manage with a VT-safe pathway while seeking old ECGs, expert help, and diagnostic clarification.
From the August 18 edition
Today, three days ago: Dobutamine. What’s the adult ED dose, and the contraindication you’d most regret missing?
Check your answer
2–20 mcg/kg/min IV infusion, titrated to perfusion/cardiac output; often requires concurrent vasopressor if hypotensive. Idiopathic hypertrophic subaortic stenosis/HOCM physiology, uncontrolled tachyarrhythmias.
From the August 11 edition
A 27-year-old trauma patient has ongoing suspected hemorrhage 90 minutes after injury. He is tachycardic and hypotensive despite an initial 500 mL crystalloid bolus. Which intervention most improves early management?
AWait for crossmatched blood before transfusion
BTranexamic acid 1 g IV over 10 minutes
CCT angiography before activating hemorrhage control
DThree additional liters of crystalloid
Reveal answer
Correct · B
Early tranexamic acid is beneficial in major traumatic bleeding when given within 3 hours, alongside blood resuscitation and definitive hemorrhage control. Crystalloid-heavy resuscitation worsens dilutional coagulopathy and should not delay blood or source control.
Journal Watch
From the FOAMed wire
Notable posts and reviews from the last week, ranked by relevance to today’s lead and source trust.
Imagine that it is 2 a.m., and a patient presents with sweating, vomiting, and an inability to... The post OPINION: When Wellness Becomes Withdrawal appeared first on ACEP Now .
In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department . 0:17 – Intro & sponsor promo 1:09 – Episode introduction 4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area 6:12 –...
We kick off July with pieces on sepsis from Haney, peds fingertip injuries from Ilene, and a case of a cranky consult with Jan and Swami. Megan and Mel work through last month’s EMA papers 1. Mel's July Update 2....
Pharmacology Corner
Two drugs for the shift
One antimicrobial and one other ED workhorse — selected daily, with sources and last-reviewed dates so every dose is cross-checkable.
Antimicrobial of the Day
Valacyclovir
Nucleoside analog antiviral (acyclovir prodrug)
Indication
Herpes zoster, genital and orolabial HSV (initial and recurrent episodes), HSV suppression, and varicella.
What’s your dose? — reveal dosing & cautions
ED Dose
Herpes zoster: 1 g PO TID x7 days. Genital HSV initial: 1 g PO BID x7–10 days; recurrent: 500 mg PO BID x3 days. Orolabial (cold sore): 2 g PO BID x1 day.
Renal Adjustment
Dose-adjust when CrCl < 50 mL/min; elderly and renally impaired patients are at higher risk of neurotoxicity.
Contraindications
Hypersensitivity to valacyclovir or acyclovir.
Interactions
Additive nephrotoxicity with other nephrotoxins; probenecid and cimetidine increase levels.
Monitoring
Renal function and hydration; neurologic status (confusion, hallucinations, especially in renal impairment).
ED Pearl
A prodrug of acyclovir with far better oral bioavailability and BID–TID dosing (vs 5×/day acyclovir). Start zoster therapy within 72 h of rash onset; in renal impairment reduce the dose and ensure hydration to avoid neurotoxicity and crystal nephropathy.
Cardiac arrest, anaphylaxis, severe asthma adjunct, peri-intubation hypotension/pressor support, and selected bradycardic shock states.
What’s your dose? — reveal dosing & cautions
ED Dose
Cardiac arrest: 1 mg IV/IO q3–5 min of 0.1 mg/mL solution. Anaphylaxis: 0.3–0.5 mg IM of 1 mg/mL into lateral thigh q5–15 min. Infusion: commonly 0.01–0.5 mcg/kg/min titrated to effect.
Renal Adjustment
No renal adjustment; titrate to clinical effect.
Contraindications
No absolute contraindication in cardiac arrest or anaphylaxis. Relative caution in severe tachyarrhythmia/ischemia when used for non-life-threatening indications.
Interactions
MAOIs/TCAs/cocaine potentiate effects; beta-blockers may blunt bronchodilation and leave unopposed alpha effects; halogenated anesthetics increase arrhythmia risk.
Monitoring
Continuous ECG, BP, perfusion, extravasation, lactate interpretation after high doses.
ED Pearl
For anaphylaxis, the route/concentration error kills: IM thigh uses 1 mg/mL; IV push arrest dosing uses 0.1 mg/mL and belongs in cardiac arrest or expert titration contexts.
For educational use only. Verify dosing against the FDA label and your institution’s pharmacy resources before administering.
ECG of the Day
Conduction
AV Block — Mobitz II
Intermittent dropped QRS complexes without progressive PR prolongation imply infranodal disease and a high risk of complete heart block.
The Tracing
A 76-year-old patient with dizziness has an ECG showing regular sinus P waves at 75 bpm. Most P waves conduct with a constant PR interval, but every third P wave is suddenly not followed by a QRS complex. The conducted QRS complexes are wide with a right bundle branch block morphology. There is no progressive PR lengthening before the dropped beat.
Constant PR intervals in conducted beats before and after a non-conducted P wave
Intermittent dropped QRS complexes without preceding PR prolongation
Often associated with a wide QRS because the block is commonly infranodal
May appear as 2:1 AV block where Mobitz I vs II cannot be proven from PR behavior alone
Can progress abruptly to complete heart block
Pearls
Mobitz II is a pacemaker rhythm, even if the patient looks okay in the moment.
A wide QRS with dropped beats should raise suspicion for infranodal disease.
When the rhythm is 2:1 AV block, you often cannot definitively classify Mobitz I vs II; risk-stratify based on QRS width, symptoms, and clinical context.
Pitfalls
Do not reassure yourself because the ventricular rate is currently acceptable; progression can be sudden.
Do not confuse blocked PACs with Mobitz II. Look for premature, abnormal P waves deforming the preceding T wave.
Atropine may not work well for infranodal block and can occasionally worsen conduction patterns.
At the Bedside
Place pacing pads, monitor continuously, evaluate reversible causes, and admit with cardiology involvement. If unstable, pace and support perfusion rather than waiting for progression.
For educational use only. Verify ECG interpretation against the LITFL entry and your institution’s practice before clinical decision-making.
Case of the Day
From the lead · Measuring Temperature
Self-Examination
Test Your Understanding
A 68-year-old man with shock and cool extremities has a temporal temperature of 36.8°C. Which next step is most appropriate?
AAccept the result as normothermia
BObtain a rectal or other core-proximal temperature
CGive ibuprofen and repeat the temporal scan
DDischarge if the lactate is normal
Reveal answer
Correct answer · B
Peripheral devices may underestimate core temperature in shock and at temperature extremes. A reliable core-proximal measurement should be obtained while resuscitation proceeds.
Study Pace4 topics today; Issue 38 of 94 — Infectious Disease (Weeks 20 A-20 B)Deadline · June 1, 2026